Category: Research News

VAPB and YIF1A regulate membrane delivery into dendrites

vapb

Marijn Kuijpers, Ka Lou Yu, Eva Teuling, Anna Akhmanova, Dick Jaarsma and Casper C. Hoogenraad. The ALS8 protein VAPB interacts with the ER–Golgi recycling protein YIF1A and regulates membrane delivery into dendrite. The EMBO Journal advance online publication 04 June Read more

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Liprin-α2 controls presynaptic composition and dynamics

liprin-alfa2

Samantha A. Spangler, Sabine K. Schmitz, Josta T. Kevenaar, Esther de Graaff, Heidi de Wit, Jeroen Demmers, Ruud F. Toonen and Casper C. Hoogenraad. Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. The Journal of Read more

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EBs enhance microtubule sensitivity to cancer drugs

EB-MTA

Mohan R, Katrukha EA, Doodhi H, Smal I, Meijering E, Kapitein LC, Steinmetz MO, Akhmanova A. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8900-5. doi: 10.1073/pnas.1300395110. Epub 2013 … Read more

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Mitochondrial Trafficking to Axons and Dendrites

Myrrhe van Spronsen, Marina Mikhaylova, Joanna Lipka, Max A. Schlager, Dave J. van den Heuvel, Marijn Kuijpers, Phebe S. Wulf, Nanda Keijzer, Jeroen Demmers, Lukas C. Kapitein, Dick Jaarsma, Hans C. Gerritsen, Anna Akhmanova, Casper C. Hoogenraad. TRAK/Milton Motor-Adaptor Proteins Read more

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Structural basis of tubulin tyrosination by TTL

Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO. Structural basis of tubulin tyrosination by tubulin tyrosine ligase.
J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub Read more

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BICD2 brings dynein and dynactin together

Splinter D, Razafsky DS, Schlager MA, Serra-Marques A, Grigoriev I, Demmers J, Keijzer N, Jiang K, Poser I, Hyman AA, Hoogenraad CC, King SJ, Akhmanova A. BICD2, dynactin and LIS1 cooperate in regulating dynein recruitment to cellular structures.
Mol Biol Read more

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DNERR in paraneoplastic cerebellar degeneration

Identification of Delta/Notch-like Epidermal Growth Factor-Related Receptor as the Tr Antigen in Paraneoplastic Cerebellar Degeneration. Esther de Graaff, Peter Maat, Esther Hulsenboom, Robert van den Berg, Martin van den Bent, Jeroen Demmers, Pieternella J. Lugtenburg, Casper C. Hoogenraad and Peter Read more

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Proteome-wide search reveals multiple new +TIPs

Jiang K, Toedt G, Montenegro Gouveia S, Davey NE, Hua S, van der Vaart B, Grigoriev I, Larsen J, Pedersen LB, Bezstarosti K, Lince-Faria M, Demmers J, Steinmetz MO, Gibson TJ, Akhmanova A.
A Proteome-wide Screen for Mammalian SxIP Motif-Containing Read more

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