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Prota AE, Magiera MM, Kuijpers M, Bargsten K, Frey D, Wieser M, Jaussi R, Hoogenraad CC, Kammerer RA, Janke C, Steinmetz MO. Structural basis of tubulin tyrosination by tubulin tyrosine ligase. J Cell Biol. 2013 Feb 4;200(3):259-70. doi: 10.1083/jcb.201211017. Epub 2013 Jan 28. Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated α-tubulin. Despite … Read more
Splinter D, Razafsky DS, Schlager MA, Serra-Marques A, Grigoriev I, Demmers J, Keijzer N, Jiang K, Poser I, Hyman AA, Hoogenraad CC, King SJ, Akhmanova A. BICD2, dynactin and LIS1 cooperate in regulating dynein recruitment to cellular structures. Mol Biol Cell. 2012 Sep 5.PMID:22956769 Cytoplasmic dynein is the major microtubule minus-end directed cellular motor. Most … Read more
Identification of Delta/Notch-like Epidermal Growth Factor-Related Receptor as the Tr Antigen in Paraneoplastic Cerebellar Degeneration. Esther de Graaff, Peter Maat, Esther Hulsenboom, Robert van den Berg, Martin van den Bent, Jeroen Demmers, Pieternella J. Lugtenburg, Casper C. Hoogenraad and Peter Sillevis Smitt Annals of Neurology 2012 71(6):815-24. PMID: 22447725 [Epub 2012 Feb 1]. Paraneoplastic cerebellar … Read more
Jiang K, Toedt G, Montenegro Gouveia S, Davey NE, Hua S, van der Vaart B, Grigoriev I, Larsen J, Pedersen LB, Bezstarosti K, Lince-Faria M, Demmers J, Steinmetz MO, Gibson TJ, Akhmanova A. A Proteome-wide Screen for Mammalian SxIP Motif-Containing Microtubule Plus-End Tracking Proteins. Curr Biol. 2012 Oct 9;22(19):1800-7. PMID:22885064 Microtubule plus-end tracking proteins (+TIPs) … Read more
Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects. Van de Water JA, Bagci-Onder T, Agarwal AS, Wakimoto H, Roovers RC, Zhu Y, Kasmieh R, Bhere D, Van Bergen En Henegouwen PMP, Shah K. Proc Natl Acad Sci U S A. 2012 Sep 25. Epub ahead of print, PMID: 23012408 The deregulation of … Read more
SLAIN2 links microtubule plus-end tracking proteins and controls microtubule dynamics in a cell-cycle dependent manner. Babet van der Vaart, Cristina Manatschal, Ilya Grigoriev, Vincent Olieric, Susana Montenegro Gouveia, Saša Bjelić, Jeroen Demmers, Ivan Vorobjev, Casper C. Hoogenraad, Michel O. Steinmetz and Anna Akhmanova. The Journal of Cell Biology 2011 Jun 13;193(6):1083-99. Epub 2011 Jun 6. … Read more
Mixed microtubules steer dynein-driven cargo transport into dendrites. Kapitein LC, Schlager MA, Kuijpers M, Wulf PS, van Spronsen M, MacKintosh FC, Hoogenraad CC. Curr Biol. 2010 Feb 23;20(4):290-9. PMID: 20137950 To establish and maintain their polarized morphology, neurons employ active transport driven by molecular motors to sort cargo between axons and dendrites. However, the basic … Read more
