Two tenure track Assistant Professor positions
We are looking for two creative and collaborative cell scientists to complement and strengthen research and teaching activities in our division. You will be challenged to set up your own independent group and develop strong research links with the other research groups within the division.
For one position we are specifically looking for a candidate focused on Mammalian Synthetic Biology, whereas the other position is more flexible. We are looking for researchers who are interested in combining advanced microscopy with genetic and optogenetic cell manipulation and/or biochemical in vitro reconstitution assays to study basic mechanisms of cell function or to engineer new functions into cells. Having strong experience in biochemical approaches is considered an advantage. Depending on the exact research area, a clear vision for potential biomedical applications of your research would be welcome.
For more information and to apply, please click here.
PhD and Postdoc positions
In the lab of Ginny Farías, 1 PhD position (4 years) is available.
Polarized sorting of proteins in neurons. Neurons are highly polarized cells with two morphologically and functionally distinct domains, the somatodendritic and axonal domains. Sorting of transmembrane proteins into the correct compartment is essential for neuronal function. However, the secretion routes required for polarized sorting in neurons remain largely unknown. By using biochemical and imaging approaches combined with innovative protein-protein interaction tools and the use of microfluidic devices, this project aims to identify novel players and routes for the polarized sorting of proteins in neurons. The applicant should hold a master’s degree in Biology, Biochemistry, Biomedical Sciences, Biophysics, Neuroscience or a related field in Life Sciences. Knowledge and experience with protein-protein interaction tools and/or proteomic data analysis is desirable. The candidate should be fluent in English and have good communication skills. To apply, please send your CV, contact for references and a motivation letter to Dr. Ginny Farías (email@example.com).
In the lab of Ginny Farías, 1 postdoc position (2 years) is available.
Organelle contacts in neurons. Cell function relies on the compartmentalization of different processes. The formation of discrete organelles ensures the segregation of incompatible processes, but at the same time they must be coordinated to ensure proper cellular function. In highly polarized cells such as neurons, this organelle coordination is much more complex because of the highly asymmetric architecture of these cells. By using biochemical and imaging approaches in neurons, this project aims to identify novel players involved in organelle contacts and elucidate their contribution to neuronal function. Experience in protein-protein interaction tools and/or proteomics data analysis is required. To apply, please send your CV and a motivation letter to Dr. Ginny Farías (firstname.lastname@example.org).
In the lab of Anna Akhmanova, 1 postdoc position (3 years) is available.
To apply, please send an email to A.Akhmanova@uu.nl
Multifactorial control of microtubule dynamics in vitro and in cells
Microtubule dynamics are regulated by a plethora of factors, the individual activities of which are known. However, it is still poorly understood how these factors work together and how their collective activity is modulated by physical barriers and interactions with other cytoskeletal structures such as actin. The aim of this project is to address these questions by combining cell biological experiments, multicomponent in vitro reconstitution assays and the use of microfabricated devices. This project is in collaboration with the groups of Marileen Dogterom at TU Delft, Gijsje Koenderink at AMOLF and Lukas Kapitein at Utrecht University.
In the lab of Anna Akhmanova, a PhD position (4 years) is available.
To apply, please send an email to A.Akhmanova@uu.nl
Microtubule organisation and membrane trafficking in metastatic cancer
Metastasis is the major cause of cancer-related mortality. It depends on the ability of cancer cells to migrate away from the primary tumour and invade distant organs. Cancer cell motility has been extensively investigated in conventional two-dimensional cell culture systems. However, recent studies firmly established that cancer cell behaviour and architecture is best studied in three-dimensional (3D) matrices, which more closely mimic the 3D physiological tumour microenvironment. In this project, we propose to investigate how microtubule dynamics and microtubule-based membrane trafficking contribute to cancer cell motility in 3D and to metastasis in mice. The project is a collaboration with the laboratories of Judith Klumperman and Patrick Derksen at UMC Utrecht.
PhD position in Biology, Virology and Pharmacy (1.0 FTE)
We are looking for a highly motivated PhD candidate who will develop nanobodies binding to conserved epitopes on viral proteins from corona and influenza viruses. After thorough characterization of their binding properties, these nanobodies will subsequently be explored for application in diagnosis, protection, and treatment of viral infection.
This project is a collaboration between Cell Biology, Neurobiology and Biophysics (Department of Biology, Faculty of Science), Pharmaceutics (Department of Pharmaceutical Sciences, Faculty of Science), and Virology (Faculty of Veterinary Medicine).