Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling.
Meiring JCM, Mahapatra V, Liu R, Gravett MSC, Morren D, Saunders HAJ, Choi SR, Pelster José A, Karhanova A, Metallidou I, Moore A, Spoelstra MFM, Grigoriev IS, Giono M, … Read more
Centriolar cap proteins CP110 and CPAP control slow elongation of microtubule plus ends.
Iyer SS, Chen F, Ogunmolu FE, Moradi S, Volkov VA, van Grinsven EJ, van Hoorn C, Wu J, Andrea N, Hua S, Jiang K, Vakonakis I, Potočnjak … Read more
A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth.
Saunders HAJ, van den Berg CM, Hoogebeen RA, Schweizer D, Stecker KE, Roepman R, Howes SC, Akhmanova A.
Nat Struct Mol Biol. 2025 Jan … Read more
Aurora B controls microtubule stability to regulate abscission dynamics in stem cells
S. Kodba, A. Öztop, E. van Berkum, E.A. Katrukha, M.K. Iwanski, W. Nijenhuis, L.C. Kapitein, A. Chaigne
https://doi.org/10.1016/j.celrep.2025.115238
Abscission is the last step of cell division. It separates … Read more
Scientists from Utrecht University have succeeded in applying advanced microscopy to visualise the activity of the widely used drug Taxol. Taxol is often used in cancer chemotherapy. A better understanding of the precise action of the drug offers starting points … Read more
Biophysicists from Utrecht University have developed a strategy for using light-emitting nanocrystals as a marker in living cells. By recording the movements of these quantum dots, they can clarify the structure and dynamics of the cytoskeleton. Their findings were published … Read more
Benjamin P. Bouchet, Ivar Noordstra, Miranda van Amersfoort, Eugene A. Katrukha, York-Christoph Ammon, Natalie D. ter Hoeve, Louis Hodgson, Marileen Dogterom, Patrick W.B. Derksen and Anna Akhmanova
Mesenchymal cell invasion requires cooperative regulation of persistent microtubule growth by SLAIN2 and … Read more
