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Controlling organelle transport and positioning with light

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Optogenetic control of organelle transport and positioning. Petra van Bergeijk, Max Adrian, Casper C. Hoogenraad, Lukas C. Kapitein. Nature DOI: doi.org/10.1038/nature14086 http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14128.html http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14086.html Proper positioning of organelles by cytoskeleton-based motor proteins underlies cellular events such as signaling, polarization, and growth. For many organelles, however, the precise connection between position and function has remained unclear, because … Read more

Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development

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Kah Wai Yau, Sam F.B. van Beuningen, Inês Cunha-Ferreira, Bas M.C. Cloin, Eljo Y. van Battum, Lena Will, Philipp Schätzle, Roderick P. Tas, Jaap van Krugten, Eugene A. Katrukha, Kai Jiang, Phebe S. Wulf, Marina Mikhaylova, Martin Harterink, R. Jeroen Pasterkamp, Anna Akhmanova, Lukas C. Kapitein, and Casper C. Hoogenraad http://dx.doi.org/10.1016/j.neuron.2014.04.019 In neurons, most microtubules … Read more

ERC Synergy Grant Akhmanova and Dogterom

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Anna Akhmanova and Marileen Dogterom aim to understand the basic principles of internal cell organization. This knowledge will eventually make it possible to control essential cellular processes such as cell movement and division. “If you want to manipulate cells, for example to grow organs or to treat cancer, you have to understand how they function”, … Read more

ERC Consolidator Grant for Casper Hoogenraad

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The research group of Hoogenraad has recently developed new imaging tools to visualize and manipulate the cytoskeleton and transport components in living neurons. With the ERC grant they will focus on the changes that occur within the microtubule cytoskeleton during the different stages of neuronal polarization and differentiation. The ultimate goal is to understand how … Read more

How botox binds to neurons

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Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GFX, Hoogenraad CC, Capitani G and Kammerer RA, Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A, Nature, 2013 Botulinum neurotoxin A (BoNT/A) belongs to the most dangerous … Read more