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ERC Starting Grant for Lukas Kapitein

Lukas Kapitein received a prestigious Starting Grant from the European Research Council. This 1.5 M€ grant is intended for excellent researchers with innovative proposals. The grant will allow Lukas Kapitein to expand the research of his lab on polarized transport in neurons. He will use super-resolution microscopy to dissect the organization of the neuronal microtubule … Read more

VAPB and YIF1A regulate membrane delivery into dendrites

vapb

Marijn Kuijpers, Ka Lou Yu, Eva Teuling, Anna Akhmanova, Dick Jaarsma and Casper C. Hoogenraad. The ALS8 protein VAPB interacts with the ER–Golgi recycling protein YIF1A and regulates membrane delivery into dendrite. The EMBO Journal advance online publication 04 June 2013; doi:10.1038/emboj.2013.131 The vesicle-associated membrane protein (VAMP) associated protein B (VAPB) is an integral membrane … Read more

Liprin-α2 controls presynaptic composition and dynamics

liprin-alfa2

Samantha A. Spangler, Sabine K. Schmitz, Josta T. Kevenaar, Esther de Graaff, Heidi de Wit, Jeroen Demmers, Ruud F. Toonen and Casper C. Hoogenraad. Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. The Journal of Cell Biology, Vol. 201, No. 6, 10 June 2013. Nerve cells communicate via specialized contact … Read more

EBs enhance microtubule sensitivity to cancer drugs

EB-MTA

Mohan R, Katrukha EA, Doodhi H, Smal I, Meijering E, Kapitein LC, Steinmetz MO, Akhmanova A. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8900-5. doi: 10.1073/pnas.1300395110. Epub 2013 May 14. Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, … Read more

Mitochondrial Trafficking to Axons and Dendrites

Myrrhe van Spronsen, Marina Mikhaylova, Joanna Lipka, Max A. Schlager, Dave J. van den Heuvel, Marijn Kuijpers, Phebe S. Wulf, Nanda Keijzer, Jeroen Demmers, Lukas C. Kapitein, Dick Jaarsma, Hans C. Gerritsen, Anna Akhmanova, Casper C. Hoogenraad. TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites. Neuron, Volume 77, Issue 3, 485-502, 6 February … Read more