Category: Research News

Controlling organelle transport and positioning with light

Optogenetic control of organelle transport and positioning. Petra van Bergeijk, Max Adrian, Casper C. Hoogenraad, Lukas C. Kapitein. Nature DOI: doi.org/10.1038/nature14086

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14128.html
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14086.html

Proper positioning of organelles by cytoskeleton-based motor proteins underlies cellular events such as signaling, polarization, and growth. … Read more

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Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development

Kah Wai Yau, Sam F.B. van Beuningen, Inês Cunha-Ferreira, Bas M.C. Cloin, Eljo Y. van Battum, Lena Will, Philipp Schätzle, Roderick P. Tas, Jaap van Krugten, Eugene A. Katrukha, Kai Jiang, Phebe S. Wulf, Marina Mikhaylova, Martin Harterink, R. Jeroen Read more

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How botox binds to neurons

Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GFX, Hoogenraad CC, Capitani G and Kammerer RA, Structural basis for recognition of synaptic vesicle protein 2C Read more

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A hyperactive kinesin causes the eye movement disorder CFEOM1

van der Vaart B, van Riel WE, Doodhi H, Kevenaar JT, Katrukha EA, Gumy L, Bouchet BP, Grigoriev I, Spangler SA, Yu KL, Wulf PS, Wu J, Lansbergen G, van Battum EY, Pasterkamp RJ, Mimori-Kiyosue Y, Demmers J, Olieric N, Read more

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VAPB and YIF1A regulate membrane delivery into dendrites

vapb

Marijn Kuijpers, Ka Lou Yu, Eva Teuling, Anna Akhmanova, Dick Jaarsma and Casper C. Hoogenraad. The ALS8 protein VAPB interacts with the ER–Golgi recycling protein YIF1A and regulates membrane delivery into dendrite. The EMBO Journal advance online publication 04 June Read more

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Liprin-α2 controls presynaptic composition and dynamics

liprin-alfa2

Samantha A. Spangler, Sabine K. Schmitz, Josta T. Kevenaar, Esther de Graaff, Heidi de Wit, Jeroen Demmers, Ruud F. Toonen and Casper C. Hoogenraad. Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. The Journal of Read more

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EBs enhance microtubule sensitivity to cancer drugs

EB-MTA

Mohan R, Katrukha EA, Doodhi H, Smal I, Meijering E, Kapitein LC, Steinmetz MO, Akhmanova A. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8900-5. doi: 10.1073/pnas.1300395110. Epub 2013 … Read more

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Mitochondrial Trafficking to Axons and Dendrites

Myrrhe van Spronsen, Marina Mikhaylova, Joanna Lipka, Max A. Schlager, Dave J. van den Heuvel, Marijn Kuijpers, Phebe S. Wulf, Nanda Keijzer, Jeroen Demmers, Lukas C. Kapitein, Dick Jaarsma, Hans C. Gerritsen, Anna Akhmanova, Casper C. Hoogenraad. TRAK/Milton Motor-Adaptor Proteins Read more

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